Ptf1a^tm3.1Cvw
Targeted Allele Detail

Summary

• Symbol: Ptf1a^tm3.1Cvw
• Name: pancreas specific transcription factor, 1a; targeted mutation 3.1, Christopher VE Wright
• MGI ID: MGI:5788433
• Synonyms: Ptf1a^delta
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^tm3.1Cvw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP site were inserted 1.7 kb upstream and 2 kb downstream of the transcriptional start site. Cre-mediated recombination removed the floxed region. (J:225995)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 28 strains or lines available

References

• Original: J:225995 Krah NM, et al., The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma. Elife. 2015;4
• All: 2 reference(s)