Gt(ROSA)26Sor^{tm1(Guca2a)Sawn}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Guca2a)Sawn}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Scott Arthur Waldman
• MGI ID: MGI:5788257
• Synonyms: Rosa-STOP^flox-Guca2a
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Guca2a)Sawn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185303
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Guca2a)Sawn} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Guca2a (MGI:102738)

• Mutation details: A stop cassette flanked by loxP sites and the full-length sequence were inserted downstream of the promoter. Cre-mediated recombination is necessary to remove the stop cassette and express the inserted gene. (J:185303)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:185303 Lin JE, et al., GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One. 2012;7(2):e31686
• All: 2 reference(s)