Prmt1^tm1Cwes
Targeted Allele Detail

Summary

• Symbol: Prmt1^tm1Cwes
• Name: protein arginine N-methyltransferase 1; targeted mutation 1, Chi Wai Eric So
• MGI ID: MGI:5788256
• Synonyms: Prmt1^f, Prmt1^flox
• Gene: Prmt1 Location: Chr7:44626179-44635844 bp, - strand Genetic Position: Chr7, 29.07 cM
• Alliance: Prmt1^tm1Cwes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231321
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 4 and 6, creating a conditional-ready allele with exons 5 and 6 floxed. (J:231321)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prmt1 Mutation: 35 strains or lines available

References

• Original: J:231321 Cheung N, et al., Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia. Cancer Cell. 2016 Jan 11;29(1):32-48
• All: 2 reference(s)