Nkx2-5^tm1.1Mwc
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm1.1Mwc
• Name: NK2 homeobox 5; targeted mutation 1.1, Mauro W Costa
• MGI ID: MGI:5788098
• Synonyms: Nkx2-5cKo
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm1.1Mwc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231297
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 1 and an FRT-flanked neomycin selection cassette and loxP site in the 3' UTR in exon 2. Subsequent flp-mediated recombination removed the neo cassette, leaving exons 1 and 2 floxed. (J:231297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 22 strains or lines available

References

• Original: J:231297 Furtado MB, et al., A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels. Differentiation. 2016 Jan-Mar;91(1-3):29-41
• All: 4 reference(s)