Mcrs1^tm1.1Ndj
Targeted Allele Detail

Summary

• Symbol: Mcrs1^tm1.1Ndj
• Name: microspherule protein 1; targeted mutation 1.1, Nabil Djouder
• MGI ID: MGI:5787979
• Synonyms: MCRS1^lox
• Gene: Mcrs1 Location: Chr15:99140698-99149838 bp, - strand Genetic Position: Chr15, 56.09 cM
• Alliance: Mcrs1^tm1.1Ndj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232965
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:232965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcrs1 Mutation: 41 strains or lines available

References

• Original: J:232965 Fawal MA, et al., MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation. Dev Cell. 2015 Apr 6;33(1):67-81
• All: 2 reference(s)