Tg(Tyr*)8748Lmon
Transgene Detail

Summary

• Symbol: Tg(Tyr*)8748Lmon
• Name: transgene insertion 8748, Lluis Montoliu
• MGI ID: MGI:5787964
• Synonyms: YRT2deltaAB, YRT2deltaAB line 8748
• Transgene: Tg(Tyr*)8748Lmon Location: unknown
• Alliance: Tg(Tyr*)8748Lmon page

Transgene origin

• Strain of Origin: Hsd:NMRI

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: This transgene contains two copies of the mouse tyrosinase gene, including all five exons, the 5' and 3' untranslated regions (UTs), and ~155 kb of upstream sequence encompassing the locus control region (LCR) regulatory elements at -12 kb, excluding the box A and box B elements. Transgenic mice were produced by pronuclear injection of mouse oocytes with the 250-kb yeast artificial chromosome (YAC) YRTdeltaAB, derived by homologous recombination of the YAC YRT2; YRT2 originated from a YAC library made from strain C3H genomic DNA. Expression of the transgene is demonstrated by its partial rescue of the pigment phenotype of albino NMRI mice. (J:211470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:211470 Giraldo P, et al., Artificial chromosome transgenesis in pigmentary research. Pigment Cell Res. 2002 Aug;15(4):258-64
• All: 1 reference(s)