Tg(Tyr*)2138Lmon
Transgene Detail

Summary

• Symbol: Tg(Tyr*)2138Lmon
• Name: transgene insertion 2138, Lluis Montoliu
• MGI ID: MGI:5787956
• Synonyms: YRT4
• Transgene: Tg(Tyr*)2138Lmon Location: unknown
• Alliance: Tg(Tyr*)2138Lmon page

Transgene origin

• Strain of Origin: Hsd:NMRI

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains a single copy of the mouse tyrosinase gene, including all five exons and the 5' and 3' untranslated regions (UTRs), but lacks the locus control region (LCR) regulatory elements. Transgenic mice were generated by pronuclear injection of mouse oocytes with a 100-kb yeast artificial chromosome (YAC), YRT4. YRT4 was produced by deletion via homologous recombination of 150 kb of DNA, including the LCR and upstream sequence, from the 250-kb YAC YRT2, which was derived from a YAC library generated from strain C3H genomic DNA. Expression of the transgene is demonstrated by its (weak) partial rescue of the pigment phenotype of albino NMRI mice. (J:223068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:223068 Montoliu L, et al., A locus control region at -12 kb of the tyrosinase gene. EMBO J. 1996 Nov 15;15(22):6026-34
• All: 4 reference(s)