Tg(Tyr)1999Lmon
Transgene Detail

Summary

• Symbol: Tg(Tyr)1999Lmon
• Name: transgene insertion 1999, Lluis Montoliu
• MGI ID: MGI:5787939
• Synonyms: YRT2
• Transgene: Tg(Tyr)1999Lmon Location: unknown
• Alliance: Tg(Tyr)1999Lmon page

Transgene origin

• Strain of Origin: Hsd:NMRI

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains a single copy of the entire mouse tyrosinase expression domain, including all five exons, the 5' and 3' untranslated regions (UTRs), and ~155 kb of 5' upstream sequences encompassing the locus control region (LCR) regulatory elements at -12 kb. Transgenic mice were generated by pronuclear injection of mouse oocytes with a 250-kb yeast artificial chromosome (YAC), YRT2, from a YAC library generated from strain C3H genomic DNA. Expression of the transgene is demonstrated by its complete rescue of the pigment phenotype of albino NMRI mice. (J:4498)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:4498 Schedl A, et al., A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice. Nature. 1993 Mar 18;362(6417):258-61
• All: 8 reference(s)