Tox^tm2.1Kay
Targeted Allele Detail

Summary

• Symbol: Tox^tm2.1Kay
• Name: thymocyte selection-associated high mobility group box; targeted mutation 2.1, Jonathan Kaye
• MGI ID: MGI:5784722
• Synonyms: Tox^TOM
• Gene: Tox Location: Chr4:6686353-6991557 bp, - strand Genetic Position: Chr4, 3.04 cM
• Alliance: Tox^tm2.1Kay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232838
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A tandem dimer tdTomato (TOM) gene lacking a transcriptional stop site was inserted immediately after and in-frame with the start ATG of exon 1. The resulting transcript codes for a chimeric peptide with the Tomato reporter N-terminal and Tox C-terminal. An FRT-flanked neo cassette that was also inserted was removed by flp-mediated recombination. (J:232838)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tox Mutation: 39 strains or lines available

References

• Original: J:232838 Seehus CR, et al., The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor. Nat Immunol. 2015 Jun;16(6):599-608
• All: 1 reference(s)