Thrbtm1Ehs
Targeted Allele Detail
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| Symbol: |
Thrbtm1Ehs |
| Name: |
thyroid hormone receptor beta; targeted mutation 1, National Institute of Environmental Health Science |
| MGI ID: |
MGI:5784668 |
| Synonyms: |
TRbeta147F |
| Gene: |
Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
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| Alliance: |
Thrbtm1Ehs page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:217014
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6
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| Allele Type: |
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Targeted (Not Specified) |
| Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 6 was replaced with a modified one in which an A-to-T point mutation results in the amino acid substitution of tyrosine with phenylalanine at position 147 (p.Y147F). A loxP site flanked neomycin resistance gene cassette was inserted into intron 6. Quantitative real-time PCR analysis revealed normal mRNA levels in the cortex of P12-P17 homozygous mutant mice.
(J:217014)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Thrb Mutation: |
39 strains or lines available
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| Original: |
J:217014 Martin NP, et al., A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRbeta, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. Endocrinology. 2014 Sep;155(9):3713-24 |
| All: |
2 reference(s) |
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Analysis Tools
