Becn1^tm1.1Yue
Targeted Allele Detail

Summary

• Symbol: Becn1^tm1.1Yue
• Name: beclin 1, autophagy related; targeted mutation 1.1, Zhenyu Yue
• MGI ID: MGI:5784545
• Synonyms: Becn1^flox
• Gene: Becn1 Location: Chr11:101179084-101193112 bp, - strand Genetic Position: Chr11, 64.58 cM, cytoband D
• Alliance: Becn1^tm1.1Yue page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232323
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:232323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Becn1 Mutation: 36 strains or lines available

References

• Original: J:232323 McKnight NC, et al., Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PLoS Genet. 2014 Oct;10(10):e1004626
• All: 9 reference(s)