Igh-J^{em1(14-1H3)Khyk}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igh-J^{em1(14-1H3)Khyk}
• Name: immunoglobulin heavy chain, joining region; endonuclease-mediated mutation 1, Kyoko Hayakawa
• MGI ID: MGI:5784543
• Synonyms: ON25, VHQ52
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Strain of Origin: (C57BL/6 x C3H)F1

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using zinc finger nucleotide (ZFN)-targeted endonuclease technology, segments 1-4 were replaced with the Q52 VDJH4 rearrangement cloned from the Q52 14-1H3 hybridoma. Mouse line ON25 was used to generate this allele. (J:232795)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

References

• Original: J:232795 Hayakawa K, et al., Loss of a chromosomal region with synteny to human 13q14 occurs in mouse chronic lymphocytic leukemia that originates from early-generated B-1 B cells. Leukemia. 2016 Jul;30(7):1510-9
• All: 3 reference(s)