Fxyd1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Fxyd1^tm1.1Geno
• Name: FXYD domain-containing ion transport regulator 1; targeted mutation 1.1, Genoway
• MGI ID: MGI:5781311
• Synonyms: PLM^3SA
• Gene: Fxyd1 Location: Chr7:30751103-30756624 bp, - strand Genetic Position: Chr7, 19.29 cM, cytoband B1
• Alliance: Fxyd1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230236
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions resulted in amino acid substitutions of alanine for serine at positions 63, 68 and 69. The predicted protein is unphosphorylatable. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted between exon 5 and 6. (J:230236)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fxyd1 Mutation: 26 strains or lines available

References

• Original: J:230236 Boguslavskyi A, et al., Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman. Cardiovasc Res. 2014 Oct 1;104(1):72-82
• All: 4 reference(s)