Dmdtm1Kmf
Targeted Allele Detail
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Symbol: |
Dmdtm1Kmf |
Name: |
dystrophin, muscular dystrophy; targeted mutation 1, Kevin M Flanigan |
MGI ID: |
MGI:5781149 |
Synonyms: |
Dup2 |
Gene: |
Dmd Location: ChrX:81992476-84249747 bp, + strand Genetic Position: ChrX, 38.38 cM, cytoband C
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Alliance: |
Dmdtm1Kmf page
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Germline Transmission: |
Earliest citation of germline transmission:
J:233298
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Hypomorph) |
Mutations: |
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Duplication, Insertion
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Mutation details: The targeting construct inserted downstream of exon 2 a loxP site, a duplicate copy of exon 2 and an FRT-flanked neomycin resistance cassette with a 3' loxP site. mRNA analysis confirms the inclusion of a duplicated exon 2 in muscle. Immunofluorescence and immunoblot analysis indicate that expression is essentially absent, although some muscle shows very low-level trace expression.
(J:233298)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dmd Mutation: |
153 strains or lines available
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Original: |
J:233298 Vulin A, et al., The first exon duplication mouse model of Duchenne muscular dystrophy: A tool for therapeutic development. Neuromuscul Disord. 2015 Nov;25(11):827-34 |
All: |
2 reference(s) |
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