Dll1^{tm4.1(Dll4)Gos}
Targeted Allele Detail

Summary

• Symbol: Dll1^{tm4.1(Dll4)Gos}
• Name: delta like canonical Notch ligand 1; targeted mutation 4.1, Achim Gossler
• MGI ID: MGI:5779556
• Synonyms: Dll1^Dll4ki
• Gene: Dll1 Location: Chr17:15587616-15597134 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Dll1^{tm4.1(Dll4)Gos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224861
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129Sv and CAST/EiJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Dll1^{tm4.1(Dll4)Gos} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dll4 (MGI:1859388)

• Mutation details: The Dll4 minigene was inserted into exon 1 at the transcription initiation site. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 1. (J:224861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dll1 Mutation: 46 strains or lines available

References

• Original: J:224861 Preusse K, et al., Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. PLoS Genet. 2015 Jun;11(6):e1005328
• All: 2 reference(s)