Hprt1^{tm5.1(CAG-Dll4,-Venus)Gos}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm5.1(CAG-Dll4,-Venus)Gos}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 5.1, Achim Gossler
• MGI ID: MGI:5779555
• Synonyms: CAG:Dll4
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm5.1(CAG-Dll4,-Venus)Gos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224861
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Hprt1^{tm5.1(CAG-Dll4,-Venus)Gos} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dll4 (MGI:1859388)

• Mutation details: The targeting construct introduced into the locus a CAG promoter, loxP site, neomycin resistance cassette, loxP2272 site, the coding sequence with an IRES and Venus reporter cassette, loxP site and loxP2272 site. Cre-mediated recombination removed the selection cassette and allowed for expression of the inserted sequences. (J:224861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:224861 Preusse K, et al., Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. PLoS Genet. 2015 Jun;11(6):e1005328
• All: 1 reference(s)