Gt(ROSA)26Sor^{tm2(CAG-ESR1)Tsa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-ESR1)Tsa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Sophia Y Tsai
• MGI ID: MGI:5779397
• Synonyms: LSLhERalpha
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-ESR1)Tsa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224544
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(CAG-ESR1)Tsa} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ESR1 (2099)

  Esr1	(MGI:1352467)

  Myc-Flag tagged

• Mutation details: The targeting construct introduced into the locus a CAG promoter, a floxed stop cassette and the human cDNA with an N-terminal Myc-FLAG tandem tag. (J:224544)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1205 strains or lines available

References

• Original: J:224544 Xu P, et al., Estrogen receptor-alpha in medial amygdala neurons regulates body weight. J Clin Invest. 2015 Jul 1;125(7):2861-76
• All: 3 reference(s)