Grin2a^tm1.1Yin
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1.1Yin
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1.1, Yo-ichi Nabeshima
• MGI ID: MGI:5779204
• Synonyms: GluN2A (N595Q)
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1.1Yin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232063
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector inserted uptream of the endogenous exon 10 a floxed neomycin resistance cassette. The targeting vector also inserted downstream of the endogenous exon 10 a loxP site, 48 nucleotide spacer sequence and a modified exon 10 with nucleotide substitutions (AAC to CAG). The substitutions results in the amino acid substitution of glutamine for asparagine at position 595 (N595Q). Cre-mediated recombination removed the selection cassette and left the endogenous exon 10 floxed. (J:232063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 66 strains or lines available

References

• Original: J:232063 Hayashi Y, et al., Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus. Mol Brain. 2014;7:44
• All: 1 reference(s)