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Snhl1ISS/IbgTejJ
QTL Variant Detail
Summary
QTL variant: Snhl1ISS/IbgTejJ
Name: sensorineural hearing loss 1; ISS/IbgTejJ
MGI ID: MGI:5776384
QTL: Snhl1  Location: unknown  Genetic Position: Chr10, Syntenic
Variant
origin
Strain of Specimen:  ISS/IbgTejJ
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:163117

Linkage analysis was performed on a mapping population of 252 male and female (ILS x ISS) RI mice (LXS, 63 strains, 4 mice/strain) to identify one genomic locus related to sensorineural hearing loss. Mice were genotyped at 11,000 SNP markers.

QTL Snhl1 maps to 54.0 - 60.0 Mb on Chromosome 10 with a peak LOD score of 15.8. ISS-derived alleles are reported to be associated with the sensorineural hearing loss phenotype. Protein-coding gene Cdh23 is suggested as the most likely candidate gene.

References
Original:  J:163117 Noben-Trauth K, et al., Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. PLoS One. 2010;5(7):e11459
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory