Selp^tm1.1Rpmc
Targeted Allele Detail

Summary

• Symbol: Selp^tm1.1Rpmc
• Name: selectin, platelet; targeted mutation 1.1, Rodger P McEver
• MGI ID: MGI:5776224
• Synonyms: Selp^KI
• Gene: Selp Location: Chr1:163942833-163977595 bp, + strand Genetic Position: Chr1, 71.42 cM
• Alliance: Selp^tm1.1Rpmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230041
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.4 kb promoter segment 5' of the translation start site is replaced with the corresponding 1.4-kb human-derived sequence. A loxP-flanked hygromycin cassette was inserted into intron 1. The loxP-flanked hygromycin cassette was removed by transient in vitro expression of Cre recombinase. (J:230041)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Selp Mutation: 56 strains or lines available

References

• Original: J:230041 Liu Z, et al., Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice. J Biol Chem. 2016 Jan 15;291(3):1441-7
• All: 1 reference(s)