Plvap^tm1.2Salm
Targeted Allele Detail

Summary

• Symbol: Plvap^tm1.2Salm
• Name: plasmalemma vesicle associated protein; targeted mutation 1.2, Marko Salmi
• MGI ID: MGI:5775967
• Gene: Plvap Location: Chr8:71950409-71964396 bp, - strand Genetic Position: Chr8, 34.43 cM
• Alliance: Plvap^tm1.2Salm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231504
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 1. Western blot analysis confirmed the absence of protein expression in the spleen, kidney and peripheral lymph nodes. (J:231504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plvap Mutation: 45 strains or lines available

References

• Original: J:231504 Rantakari P, et al., The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. Nat Immunol. 2015 Apr;16(4):386-96
• All: 3 reference(s)