Nptn^tm1.2Mtg
Targeted Allele Detail

Summary

• Symbol: Nptn^tm1.2Mtg
• Name: neuroplastin; targeted mutation 1.2, Dirk Montag
• MGI ID: MGI:5775785
• Synonyms: Np^-, Nptn^tmdeltaexon1
• Gene: Nptn Location: Chr9:58489504-58560162 bp, + strand Genetic Position: Chr9, 31.79 cM
• Alliance: Nptn^tm1.2Mtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212431
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was floxed and removed by cre-mediated recombination. Western blot analysis confirmed the absence of both isoforms in the brain. (J:212431, J:232022)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nptn Mutation: 36 strains or lines available

References

• Original: J:212431 Herrera-Molina R, et al., Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. J Biol Chem. 2014 Mar 28;289(13):8973-88
• All: 4 reference(s)