Pclo^tm1.1Mver
Targeted Allele Detail

Summary

• Symbol: Pclo^tm1.1Mver
• Name: piccolo (presynaptic cytomatrix protein); targeted mutation 1.1, Matthijs Verhage
• MGI ID: MGI:5775083
• Synonyms: Pclo^SA
• Gene: Pclo Location: Chr5:14564932-14913473 bp, + strand Genetic Position: Chr5, 6.27 cM, cytoband A2
• Alliance: Pclo^tm1.1Mver page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225358
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 19 was replaced with a floxed neomycin resistance cassette and a modified exon 19 in which an T to A point mutation results in the amino acid substitution of alanine for serine at position 474 (S4742A). Cre-mediated recombination removed the selection cassette. (J:225358)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pclo Mutation: 267 strains or lines available

References

• Original: J:225358 Giniatullina A, et al., Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences. Neuroscience. 2015 Aug 6;300:518-38
• All: 1 reference(s)