Tg(B2M,HLA-B*27:05)56-3Trg
Transgene Detail

Summary

• Symbol: Tg(B2M,HLA-B*27:05)56-3Trg
• Name: transgene insertion 56-3, Joel D Taurog
• MGI ID: MGI:5770329
• Synonyms: line 56-3, Tg(B2M)1Trg, Tg(B2M)1Trg Tg(HLA-B27)1Trg, Tg(HLA-B)1Trg, Tg(HLA-B27)1Trg
• Transgene: Tg(B2M,HLA-B*27:05)56-3Trg Location: unknown
• Alliance: Tg(B2M,HLA-B*27:05)56-3Trg page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(B2M,HLA-B*27:05)56-3Trg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  B2M (567)

  B2m	(MGI:88127)

• Mutation details: The HLA-B*27:05 and human B2M constructs were co-injected and are believed to have co-integrated because they have co-segregated through extensive breeding. Splenic expression of both was confirmed. This insertion is believed to be homozygous lethal. (J:74451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Because separate constructs were injected this transgenic insertion was called by two separate marker sybmols for many years, Tg(B2M)1Trg and Tg(HLA-B27)1Trg, but this was corrected in 2016 to a single marker indicative of probable co-integration.

References

• Original: J:74451 Taurog JD, et al., HLA-B27 Transgenic Mice as Potential Models of Human Disease, in Transgenic Mice and Mutants in MHC Research. 1990:268-75.
• All: 2 reference(s)