Mef2d^tm1.1Tfur
Targeted Allele Detail

Summary

• Symbol: Mef2d^tm1.1Tfur
• Name: myocyte enhancer factor 2D; targeted mutation 1.1, Takahisa Furukawa
• MGI ID: MGI:5767097
• Synonyms: Mef2d^flox
• Gene: Mef2d Location: Chr3:88049679-88079393 bp, + strand Genetic Position: Chr3, 38.78 cM
• Alliance: Mef2d^tm1.1Tfur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230346
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 2 through 4 floxed. (J:230346)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mef2d Mutation: 63 strains or lines available

References

• Original: J:230346 Omori Y, et al., Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes Cells. 2015 May;20(5):408-26
• All: 1 reference(s)