Inpp4b^tm1.2Tssk
Targeted Allele Detail

Summary

• Symbol: Inpp4b^tm1.2Tssk
• Name: inositol polyphosphate-4-phosphatase, type II; targeted mutation 1.2, Takehiko Sasaki
• MGI ID: MGI:5766258
• Synonyms: Inpp4b^delta
• Gene: Inpp4b Location: Chr8:82069185-82854543 bp, + strand Genetic Position: Chr8, 39.02 cM
• Alliance: Inpp4b^tm1.2Tssk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227240
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 21. A floxed neomycin resistance cassette was inserted downstream of exon 21. Cre-mediated recombination removed the selection cassette and exon 21. (J:227240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inpp4b Mutation: 69 strains or lines available

References

• Original: J:227240 Kofuji S, et al., INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015 Jul;5(7):730-9
• All: 4 reference(s)