Cep290^tm1Asw
Targeted Allele Detail

Summary

• Symbol: Cep290^tm1Asw
• Name: centrosomal protein 290; targeted mutation 1, Anand Swaroop
• MGI ID: MGI:5763745
• Synonyms: Cep290^ko
• Gene: Cep290 Location: Chr10:100323410-100409527 bp, + strand Genetic Position: Chr10, 51.48 cM
• Alliance: Cep290^tm1Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222403
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 4 were replaced with a beta-gal reporter cassette and a floxed neomycin resistance cassette. (J:222403)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cep290 Mutation: 123 strains or lines available

References

• Original: J:222403 Rachel RA, et al., CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies. Hum Mol Genet. 2015 Jul 1;24(13):3775-91
• All: 2 reference(s)