Musktm1.2Ics
Targeted Allele Detail
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Symbol: |
Musktm1.2Ics |
Name: |
muscle, skeletal, receptor tyrosine kinase; targeted mutation 1.2, Mouse Clinical Institute |
MGI ID: |
MGI:5763564 |
Synonyms: |
MuSKdeltaCRD |
Gene: |
Musk Location: Chr4:58285962-58374303 bp, + strand Genetic Position: Chr4, 31.87 cM
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Alliance: |
Musktm1.2Ics page
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Germline Transmission: |
Earliest citation of germline transmission:
J:221340
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
BALB/cN
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A self-excising neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 9. An additional loxP site was inserted downstream of exon 11. Cre-mediated recombination removed the selection cassette and exons 9 through 11. The predicted protein lacks the cysteine-rich domain.
(J:221340)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Musk Mutation: |
42 strains or lines available
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Original: |
J:221340 Messeant J, et al., MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance. J Neurosci. 2015 Mar 25;35(12):4926-41 |
All: |
1 reference(s) |
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