Serpine1^tm1.1Vlp
Targeted Allele Detail

Summary

• Symbol: Serpine1^tm1.1Vlp
• Name: serine (or cysteine) peptidase inhibitor, clade E, member 1; targeted mutation 1.1, Victoria A Ploplis
• MGI ID: MGI:5763484
• Synonyms: PAI-1^R101A/Q123K
• Gene: Serpine1 Location: Chr5:137090358-137101122 bp, - strand Genetic Position: Chr5, 76.16 cM
• Alliance: Serpine1^tm1.1Vlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230643
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 3 was replaced with a modified one in which nucleotide substitutions result in the amino acid substitutions of alanine for arginine at position 101 (R101A) and lysine for glutamine at position 123 (Q123K). Flp-mediated recombination removed the FRT- and loxP-flanked neomycin resistance cassette inserted downstream of the modified exon 3. (J:230643)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpine1 Mutation: 23 strains or lines available

References

• Original: J:230643 Narasaki R, et al., The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. J Thromb Haemost. 2012 Dec;10(12):2618-21
• All: 2 reference(s)