Smg6^tm1.2Zqw
Targeted Allele Detail

Summary

• Symbol: Smg6^tm1.2Zqw
• Name: SMG6 nonsense mediated mRNA decay factor; targeted mutation 1.2, Zhao-Qi Wang
• MGI ID: MGI:5763145
• Synonyms: Smg6^delta
• Gene: Smg6 Location: Chr11:74816665-75055274 bp, + strand Genetic Position: Chr11, 45.76 cM
• Alliance: Smg6^tm1.2Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222980
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette was inserted downstream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 through 4. (J:222980)

Expression

In Mice Carrying this Mutation:

28 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smg6 Mutation: 98 strains or lines available

References

• Original: J:222980 Li T, et al., Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. EMBO J. 2015 Jun 12;34(12):1630-47
• All: 2 reference(s)