Apoc2^em2Arem
Endonuclease-mediated Allele Detail

Summary

• Symbol: Apoc2^em2Arem
• Name: apolipoprotein C2; endonuclease-mediated mutation 1, Alan Remaley
• MGI ID: MGI:5763017
• Gene: Apoc2 Location: Chr7:19405504-19411866 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoc2^em2Arem page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated
• Mutation: Intragenic deletion
• Mutation details: Zinc finger technology induced a 9 bp deletion in exon 3 that results in the deletion of 3 amino acids. This allele is predicted to produce a C-II-a, short mimetic peptide. (J:227332)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoc2 Mutation: 5 strains or lines available

References

• Original: J:227332 Sakurai T, et al., Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide. J Pharmacol Exp Ther. 2016 Feb;356(2):341-53
• All: 2 reference(s)