Gfer^tm1.2Crg
Targeted Allele Detail

Summary

• Symbol: Gfer^tm1.2Crg
• Name: growth factor, augmenter of liver regeneration; targeted mutation 1.2, Chandrashekhar R Gandhi
• MGI ID: MGI:5762605
• Synonyms: ALR^null
• Gene: Gfer Location: Chr17:24912164-24915065 bp, - strand Genetic Position: Chr17, 12.48 cM
• Alliance: Gfer^tm1.2Crg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227242
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. (J:227242)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfer Mutation: 22 strains or lines available

References

• Original: J:227242 Gandhi CR, et al., Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice. Gastroenterology. 2015 Feb;148(2):379-391.e4
• All: 1 reference(s)