Tg(Prnp/PRNP)1Drb
Transgene Detail
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Symbol: |
Tg(Prnp/PRNP)1Drb |
Name: |
transgene insertion 1, David R Brown |
MGI ID: |
MGI:5762584 |
Synonyms: |
PrP Chicken-repeats, Tg(Prnp-chkhexrepeat) |
Transgene: |
Tg(Prnp/PRNP)1Drb Location: unknown
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Alliance: |
Tg(Prnp/PRNP)1Drb page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Prnp/PRNP)1Drb expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
kudu |
PRNP |
ENA Sequence: X74771.1 |
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Mutation details: This transgene encodes a chimeric prion protein in which the N-terminal octameric repeat region of the mouse protein, comprising four tandem repeats of the amino acid sequence PHGGGWGQ, has been replaced by the analogous region from the chicken prion protein, which contains nine tandem copies of the hexapeptide sequence PHNPGY. Mice homozygous for the transgene and for a knockout allele of the endogenous Prnp gene express the chimeric protein at wild-type levels with correct membrane location and orientation. The substitution affects the metal-coordinating properties of the protein.
(J:169366)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:169366 MouseBookTM, Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished. 2005-2013; |
All: |
1 reference(s) |
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