Igh^tm8Cog
Targeted Allele Detail

Summary

• Symbol: Igh^tm8Cog
• Name: immunoglobulin heavy chain complex; targeted mutation 8, Michel Cogne
• MGI ID: MGI:5758906
• Synonyms: muepsilonKI, Rr185^tm8Cog
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222037
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the Igh Smu sequence with a loxP site, the human IGH mu constant sequence, a loxP site flanked neomycin resistance gene cassette, and the human epsilon constant sequence. Cre-mediated recombination is required to achieve expression of the Cepsilon sequence. (J:222037)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:222037 Laffleur B, et al., Self-Restrained B Cells Arise following Membrane IgE Expression. Cell Rep. 2015 Feb 12
• All: 2 reference(s)