Dnmt3l^tm1Skto
Targeted Allele Detail

Summary

• Symbol: Dnmt3l^tm1Skto
• Name: DNA methyltransferase 3-like; targeted mutation 1, Steen KT Ooi
• MGI ID: MGI:5756052
• Synonyms: Dnmt3L^A
• Gene: Dnmt3l Location: Chr10:77878121-77899456 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dnmt3l^tm1Skto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222035
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 5 was modified (A to C) to encode the amino acid substitution of alanine for aspartic acid at position 124 (D124A). A loxP site is present downstream of exon 7. No selection cassette is present in the allele. (J:222035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3l Mutation: 52 strains or lines available

References

• Original: J:222035 Vlachogiannis G, et al., The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis. Cell Rep. 2015 Feb 12
• All: 1 reference(s)