Kctd12^tm1.1Bet
Targeted Allele Detail

Summary

• Symbol: Kctd12^tm1.1Bet
• Name: potassium channel tetramerisation domain containing 12; targeted mutation 1.1, Bernhard Bettler
• MGI ID: MGI:5756044
• Gene: Kctd12 Location: Chr14:103214017-103220073 bp, - strand Genetic Position: Chr14, 51.55 cM
• Alliance: Kctd12^tm1.1Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227160
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced the coding sequence. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein in the brain. (J:227160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kctd12 Mutation: 8 strains or lines available

References

• Original: J:227160 Cathomas F, et al., Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders. Transl Psychiatry. 2015;5:e510
• All: 4 reference(s)