Intu^dtm
Chemically induced Allele Detail

Summary

• Symbol: Intu^dtm
• Name: inturned planar cell polarity protein; double-thumb
• MGI ID: MGI:5755448
• Gene: Intu Location: Chr3:40585559-40659206 bp, + strand Genetic Position: Chr3, 19.46 cM
• Alliance: Intu^dtm page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a non-synonymous T to A substitution resulting in the replacement of a hydrophobic amino acid Isoleucine with a hydrophilic amino acid Asparagine at position 813 (I813N) near the C-terminal end of the 942-amino acid protein. (J:222441)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Intu Mutation: 45 strains or lines available

References

• Original: J:222441 Chang R, et al., A hypomorphic allele reveals an important role of inturned in mouse skeletal development. Dev Dyn. 2015 Jun;244(6):736-47
• All: 1 reference(s)