Klf1^MommeD11
Chemically induced Allele Detail

Summary

• Symbol: Klf1^MommeD11
• Name: Kruppel-like transcription factor 1 (erythroid); modifier of murine metastable epialleles, D11
• MGI ID: MGI:5752591
• Gene: Klf1 Location: Chr8:85628611-85631920 bp, + strand Genetic Position: Chr8, 41.3 cM
• Alliance: Klf1^MommeD11 page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T-to-A transversion that generates a new stop codon (p.C330*) in the sequence encoding the second zinc-finger. (J:223531)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf1 Mutation: 22 strains or lines available

References

• Original: J:223531 Sorolla A, et al., Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of alpha-globin transgene variegation. Genomics. 2015 Feb;105(2):116-22
• All: 1 reference(s)