Myc^tm2.1Fwa
Targeted Allele Detail

Summary

• Symbol: Myc^tm2.1Fwa
• Name: Myc proto-oncogene, bHLH transcription factor; targeted mutation 2.1, Frederick W Alt
• MGI ID: MGI:5752187
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm2.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219563
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was inserted into intron 1 and a loxP-flanked neomycin selection cassette was inserted 3' to exon 3. Cre mediated recombination removed the neo cassette and the floxed exon. (J:67222)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 42 strains or lines available

References

• Original: J:219563 Hofmann JW, et al., Reduced expression of MYC increases longevity and enhances healthspan. Cell. 2015 Jan 29;160(3):477-88
• All: 5 reference(s)