Gt(ROSA)26Sor^{tm1(Mir142)Sbel}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Mir142)Sbel}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Saverio Bellusci
• MGI ID: MGI:5752061
• Synonyms: Gt(ROSA)26Sor^{tm1(CAG-Mir142)Sbel}, miR142flox_gof, Rosa26-LSL-miR-142, Rosa26R^miR-142
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Mir142)Sbel} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:290284
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Mir142)Sbel} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir142 (MGI:2676827)

• Mutation details: The following cassette was inserted into intron 1 of the the Rosa26 locus: an Ad splice acceptor site, a conditional STOP cassette (corresponding to a loxP site, PGK promoter, neomycin resistance gene, PGK poly(A) signal, 3x SV40 poly(A) signal sequence and a second loxP site), followed by the microRNA 142 sequence with bovine GH poly(A) signal sequence. (J:290284)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:290284 Shrestha A, et al., A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development. Cell Mol Life Sci. 2019 Jul;76(14):2817-2832
• All: 1 reference(s)