Prkdc^tm1Jchu
Targeted Allele Detail

Summary

• Symbol: Prkdc^tm1Jchu
• Name: protein kinase, DNA activated, catalytic polypeptide; targeted mutation 1, Jay H Chung
• MGI ID: MGI:5752036
• Synonyms: DNA-PKcs^fl
• Gene: Prkdc Location: Chr16:15455730-15660099 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Prkdc^tm1Jchu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221358
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 81 and an FRT flanked neo cassette and loxP site were inserted in intron 83 via homologous recombination. (J:221358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkdc Mutation: 400 strains or lines available

References

• Original: J:221358 Mishra A, et al., Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun. 2015;6:6224
• All: 6 reference(s)