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Setdb2tm1Desr
Targeted Allele Detail
Summary
Symbol: Setdb2tm1Desr
Name: SET domain, bifurcated 2; targeted mutation 1, David E Symer
MGI ID: MGI:5751798
Synonyms: Setdb2GT
Gene: Setdb2  Location: Chr14:59639458-59678329 bp, - strand  Genetic Position: Chr14, 31.48 cM
Alliance: Setdb2tm1Desr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222611
Parent Cell Line:  v6.4 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutations:    Insertion, Insertion of gene trap vector
 
Mutation detailsA gene trap (containing an FRT site, loxP site, pGK/EM7 dual promoter, strong splice acceptor from En2, neomycin resistance cassette, polyadenylation sequence, FRT site and loxP) was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Western blot analysis confirmed reduced protein expression in the spleen, lung and bone marrow-derived macrophages. (J:222611)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Setdb2 Mutation:  51 strains or lines available
References
Original:  J:222611 Schliehe C, et al., The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol. 2015 Jan;16(1):67-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory