Arf6^tm1.1Gdp
Targeted Allele Detail

Summary

• Symbol: Arf6^tm1.1Gdp
• Name: ARF GTPase 6; targeted mutation 1.1, Gilbert Di Paolo
• MGI ID: MGI:5751713
• Synonyms: Arf6^Flox
• Gene: Arf6 Location: Chr12:69418924-69420557 bp, + strand Genetic Position: Chr12, 28.81 cM
• Alliance: Arf6^tm1.1Gdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240070
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to have a loxP site upstream, and a FRT-flanked neo cassette with 3' loxP site downstream of the entire coding region (~4000 bp) of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:240070)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arf6 Mutation: 11 strains or lines available

References

• Original: J:240070 Marquer C, et al., Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. Nat Commun. 2016 Jun 23;7:11919
• All: 4 reference(s)