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Pcaretm1Kpal
Targeted Allele Detail
Summary
Symbol: Pcaretm1Kpal
Name: photoreceptor cilium actin regulator; targeted mutation 1, Krzysztof Palczewski
MGI ID: MGI:5751702
Synonyms: BC-
Gene: Pcare  Location: Chr17:72050919-72059904 bp, - strand  Genetic Position: Chr17, 42.67 cM
Alliance: Pcaretm1Kpal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220866
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neo cassette via homologous recombination. qRT-PCR confirmed a virtually complete lack of RNA transcripts in the eyes of homozygous mutant mice. (J:220866)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 52018 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcare Mutation:  39 strains or lines available
References
Original:  J:220866 Kevany BM, et al., Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Hum Mol Genet. 2015 May 1;24(9):2627-40
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory