Kras^tm2.1Cmco
Targeted Allele Detail

Summary

• Symbol: Kras^tm2.1Cmco
• Name: Kras proto-oncogene, GTPase; targeted mutation 2.1, Christopher M Counter
• MGI ID: MGI:5751536
• Synonyms: Kras^C118S
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm2.1Cmco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223079
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Cysteine codon 118 in exon 3 was changed to serine (c.353G>C) (p.C118S). Cre-mediated recombination removed the floxed neomycin resistance cassette that was inserted into intron 3. (J:223079)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 68 strains or lines available

References

• Original: J:223079 Huang L, et al., Decreased tumorigenesis in mice with a Kras point mutation at C118. Nat Commun. 2014;5:5410
• All: 1 reference(s)