Tg(H2-Ab1)GBQRhd
Transgene Detail

Summary

• Symbol: Tg(H2-Ab1)GBQRhd
• Name: transgene insertion GBQ, Rikard Holmdahl
• MGI ID: MGI:5751520
• Synonyms: Ab^GBQ, GBQ
• Transgene: Tg(H2-Ab1)GBQRhd Location: unknown
• Alliance: Tg(H2-Ab1)GBQRhd page

Transgene origin

• Strain of Origin: (C3.NB-H2^p/SnJ x B10.P-H2^p/SgTu)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-Ab1)GBQRhd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-Ab1 (MGI:103070)

• Mutation details: A 11-kb genomic DNA fragment containing the entire H2-Ab^p gene, including 2.4 kb of 5'- and 3.5 kb of 3'-flanking sequence, was modified by replacement of the second exon with that of the H2-Ab^q allele, which differs from Ab^p at codons 85, 86, 88, and 89. An additional 1.1 kb of 5' flanking sequence from the H2-Ab1^b gene was inserted upstream of the H2-Ab^p/Ab^q fusion gene to ensure the inclusion of all regulatory elements necessary for normal MHC class II expression. (J:19734)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:19734 Brunsberg U, et al., Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritis. Eur J Immunol. 1994 Jul;24(7):1698-702
• All: 1 reference(s)