Trex1tm1.1Fwpe
Targeted Allele Detail
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Symbol: |
Trex1tm1.1Fwpe |
Name: |
three prime repair exonuclease 1; targeted mutation 1.1, Fred W Perrino |
MGI ID: |
MGI:5751220 |
Synonyms: |
TREX1D18N |
Gene: |
Trex1 Location: Chr9:108887000-108888791 bp, - strand Genetic Position: Chr9, 59.63 cM
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Alliance: |
Trex1tm1.1Fwpe page
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Autoimmune phenotype in Trex1tm1.1Fwpe/Trex1tm1.1Fwpe mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:220965
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Parent Cell Line: |
XSV1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Dominant negative) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: The coding exon and 5'UTR were replaced with sequence with a C to T mutation in the 5' UTR and a D18N mutation in the exon and a floxed neo cassette was inserted in the 3' region via homologous recombination. Cre mediated recombination removed the neo cassette.
(J:220965)
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Generation of the Trex1tm1.1Fwpe allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trex1 Mutation: |
22 strains or lines available
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Original: |
J:220965 Grieves JL, et al., Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5117-22 |
All: |
2 reference(s) |
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