Hhatl^tm1Hta
Targeted Allele Detail

Summary

• Symbol: Hhatl^tm1Hta
• Name: hedgehog acyltransferase-like; targeted mutation 1, Hiroshi Takeshima
• MGI ID: MGI:5750930
• Gene: Hhatl Location: Chr9:121613082-121621573 bp, - strand Genetic Position: Chr9, 72.62 cM, cytoband F4
• Alliance: Hhatl^tm1Hta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220810
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette in inverse orientation replaced a genomic region containing 7 exons including the ATG start site. Western blot analysis confirmed the absence of expression in skeletal muscle from homozygous mice. (J:220810)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hhatl Mutation: 37 strains or lines available

References

• Original: J:220810 Van B, et al., Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation. FEBS Lett. 2015 Apr 28;589(10):1095-104
• All: 1 reference(s)