Lrrk2^tm1.1Hlme
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1.1Hlme
• Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Heather L Melrose
• MGI ID: MGI:5750894
• Synonyms: G2019S KI
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1.1Hlme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223350
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 41 was replaced with a modified exon 41 with nucleotide substitutions (GGG to AGC) that results in the substitution of serine for glycine at position 2019 (G2019S). A floxed neomycin cassette was placed immediately downstream of exon 41 and was removed via cre-mediated recombination. Kinase activity is increased about 1.8-fold in heterozygotes and about 4-fold in homozygotes. (J:223350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 156 strains or lines available

References

• Original: J:223350 Yue M, et al., Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice. Neurobiol Dis. 2015 Jun;78:172-95
• All: 8 reference(s)