Npy^tm1(cre)Zman
Targeted Allele Detail

Summary

• Symbol: Npy^tm1(cre)Zman
• Name: neuropeptide Y; targeted mutation 1, Boris Zemelman
• MGI ID: MGI:5750089
• Synonyms: NPY-Cre
• Gene: Npy Location: Chr6:49799690-49806487 bp, + strand Genetic Position: Chr6, 24.04 cM, cytoband B3
• Alliance: Npy^tm1(cre)Zman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229004
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv or C57BL/6J

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Npy^tm1(cre)Zman expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Npy (MGI:97374)

• Mutation details: A cassette encoding IRES, Cre recombinase, and an FRT-flanked neomycin selection cassette is inserted into the mouse Npy locus 3' UTR between the coding sequence stop codon and the polyadenylation site. (J:229004)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Npy (mouse) Summary of all recombinase alleles driven by Npy. Alliance mouse Npy gene page
User Notes:	Additional information submitted by the research community Additional information submitted by the research community Expression has been reported in interneurons at the strata radiatum/lacunosummoleculare (SR/LM) border and in other interneurons in other layers, including some oriens lacunosum-moleculare (O-LM) neurons in strata oriens (SO) and some putative neurogliaform cells in strata lacunosummoleculare (SLM).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npy Mutation: 19 strains or lines available

Notes

"The targeting construct was electroporated into hybrid C57Bl/6J-129/SV stem cells." (J:229004)

References

• Original: J:229004 Milstein AD, et al., Inhibitory Gating of Input Comparison in the CA1 Microcircuit. Neuron. 2015 Sep 23;87(6):1274-89
• All: 11 reference(s)